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Jill Carnahan, MD Yeah, exactly

The good news is that severe side effects are very rare, including joint and muscle aches and pains, numbness, and swelling

This makes them particularly effective for reducing fine lines, wrinkles, and sagging skin

The original weight management approval was based on the STEP (Semaglutide Treatment Effect in People with obesity) clinical trial program, which enrolled over 4,500 participants without diabetes

Sanjay Bharti, MD

In a db/db mouse model of type 2 diabetes, dapagliflozin treatment for 12 weeks inhibited the expression of TGF- , MCP-1, osteopontin and ICAM-1, and thereby inhibited diabetes-induced inflammation in the kidneys (154)