In individuals with congenital hyperinsulinism due to inactivating mutations in the genes encoding the beta cell K ATP channels, the GLP-1 receptor antagonist, exendin-(9-39), increases fasting plasma glucose and prevents protein-induced hypoglycemia
Overall, it is well-tolerated, but peripheral edema and transient increases in appetite are common
The MHRA and EMA have reviewed this evidence, and the Summary of Product Characteristics (SmPC) for semaglutide (Ozempic, Wegovy) specifically advises that patients with diabetic retinopathy should be closely monitored during treatment, particularly during periods of rapid glycaemic improvement
Ferritin 14, TSAT 11%. A Assessed: Iron deficiency anemia secondary to chronic GI blood loss, currently stable. T Treated: Ferrous sulfate 325 mg TID, repeat CBC in 8 weeks. A problem list entry of anemia with no MEAT support will not survive a RADV audit
There are good reasons for this popularity, backed by both research and practical experience
That happens to be when estrogen levels peak