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This dual control of insulin and glucagon has the benefit that the plasma glucose concentration is kept in the normal fasting range to avoid hypoglycemia caused by overstimulation of insulin

This is significant because leptin has its primary effects in the brain but does not cross the blood-brain barrier as readily as MT-2

Although the new drug treatments have been shown to slow cognitive decline, the aggregate impact on health care use and costs is not yet known

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Nonclinically, bremelanotide inhibited food intake in rats (107)

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