Here, we demonstrated that long-term oscillating glucose challenge in vivo resulted in desensitization of insulin secretion due to -cell mass exhaustion, which was caused by -cell dedifferentiation
doi: 10.1016/j.fertnstert.2023.06.001 71 NoyLBarneaIMirskySKKamberDLeviMShakedNT
Ramires JniorOVAlvesBDSBarrosPABRodriguesJLFerreiraSPMonteiroLKSet al
The intranasal route was chosen for its ability to bypass the blood-brain barrier, allowing the peptide to reach brain tissue more effectively while minimizing systemic copper exposure
Skillern PG, Crile G Jr, McCullaugh EP, Hazard JB, Lewis LA, Brown H
Reduced Glutathione has powerful antioxidant properties that combat oxidative stress and slow premature aging