Considering the expansive spread of GLP 1R throughout the systems in body and identifying the potential to modulate its effects with GLP-1RA is a paradigm shift in early intervention
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The GLP-1R, widely expressed in many systems and organs, has a neuroprotective effect, supporting intracellular homeostasis and reducing damage to neurons caused by oxidative stress, inflammatory cascades, apoptotic signals, and ischemic conditions [11]
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I assess the appropriateness of the medication carefully and monitor closely when [these patients] are on a GLP-1 agonist. The caution is warranted, according to John Batsis, MD, an associate professor of medicine in the Division of Geriatric Medicine at the University of North Carolina at Chapel Hill School of Medicine, particularly because of the lack of clinical data on the specific impact of GLP-1 medications on older adults
