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Chemical penetration enhancers are used to modify the skin barrier's physicochemical characteristics, facilitating drug permeation [6]

Ferroptosis in macrophages Macrophages are key players in wound healing, responsible for regulating inflammation, clearing cell debris, and coordinating tissue repair [29]

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TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation