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The reaction of o-quinones with the thiol group of Keap1 cysteines is an essential mechanism for the activation of the NRF2/ARE axis, regulating and ensuring the appropriateness of redox responses and oxidative signaling factors [165], (Figure 11)

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This was demonstrated to be dose- and time-dependent, where LPS-induced increases in circulating IL-6 (30 min) preceded that of both total and active GLP-1 (120 min) (Kahles et al., 2014)

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