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The folate-cobalamin interaction is pivotal for normal synthesis of purines and pyrimidines and the transfer of the methyl group to cobalamin is essential for the adequate supply of tetrahydrofolate, the substrate for metabolic steps that require folate

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11 The nonpeptide GLP-1 RA orforglipron (Foundayo) was approved in April 2026, becoming the second oral IBT available for chronic weight management

Maintenance: Use once every 10-15 days followed by sunscreen and moisturizer

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