We would recommend trying weekly injections (if youre able to tolerate the side effects) for at least three full months before making a decision either way
Apply gentle pressure with gauze for 5-10 seconds
However, optimizing your timing to maximize protein and nutrient intake (by aligning higher-appetite days with protein-rich meals) can help mitigate this side effect indirectly
In particular, the RefluxStop method, which I have further developed (more than 200 operations to date in Bern), has an excellent success rate even in difficult cases, with significantly fewer side effects
Key differences include: Longer half-life: Semaglutide is chemically modified to resist breakdown by DPP-4 and has a half-life of about a week, allowing for once-weekly dosing (e.g., in drugs like Ozempic or Wegovy)
Nature Immunology 13(4): 352357.