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G., & Chan, M

5-Amino-1MQ inhibits NNMT, an enzyme that depletes NAD+ and promotes fat storage

In aged skeletal muscle models, NNMT inhibitor treatment increased proliferating/active muscle stem cells by 60-75% following injury, myofiber cross-sectional area increased 1.8-fold at one week post-injury with high-dose treatment, and peak torque of injured muscle increased by 67% compared to control (p = 0.033), with no untoward systemic toxicity observed in plasma chemistry markers (Neelakantan et al., 2019)

Recent metabolic studies suggest TB500 may act as a prodrug, cleaving to an active pentapeptide metabolite that drives biological activity [12]

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