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Dysregulation of copper ions can disturb lipid metabolism, resulting in oxidative stress, mitochondrial damage and endothelial cell dysfunction (14), and induce atherosclerosis and other cardiovascular diseases such as arrhythmia and cardiomyopathy (15)

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[21] the parties settled in 2008, with Palatin retaining rights to bremelanotide, returning rights to melanotan-II to Competitive Technologies, and paying $800,000