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Discovery of a potent, selective, and orally bioavailable c-met inhibitor: 1-(2-Hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458)

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(1988), published in FEBS Letters, demonstrated that GHK-Cu significantly stimulated collagen synthesis, proteoglycan production, angiogenesis, and wound closure across multiple animal and cell models

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