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These results indicate that exogenous GSH acidifies the culture medium in a dosage dependent manner

Excessive free radicals are associated with many diseases: atherosclerosis, cataracts, cancer, Alzheimers, osteoarthritis, immune dysfunction, and more

J Biol Chem 286 , 1834718353, (2011)

This creates a devastating feedback loop: the lack of glutathione allows oxidative stress to run rampant, which further impairs the methylation cycle, which in turn prevents the production of more glutathione

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