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We hypothesized that this was because of tesofensines ability to modulate neuronal activity in the LH

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Sixty patients aged 65 and older were randomly assigned to either a loading dose regimen (daily administration for 14 days followed by weekly doses) or a regimen without a loading dose (administration every 3 days) over 90 days

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Most research protocols don't require accounting for overfill at the individual-dose level