Traditionally, glucagon was viewed as an antagonist to insulin, raising blood sugar
It works by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1), which helps regulate blood sugar levels and appetite
drug should appear clear and colorless Do not use semaglutide if particulate matter and coloration observed Instructions for Wegovy SC Injection (Video, Click Play) Side Effects Very Common: may affect more than 1 in 10 people feeling or being sick (nausea or vomiting) diarrhea constipation stomach pain feeling weak or tired headache these usually goes away over time Common: may affect up to 1 in 10 people feeling dizzy upset stomach or indigestion burping gas (flatulence) bloating of the stomach inflamed stomach (gastritis) the signs include stomach-ache, feeling sick (nausea) or being sick (vomiting) reflux or heartburn also called gastro-esophageal reflux disease hair loss injection site reactions low blood sugar (hypoglycaemia) in patients with diabetes low blood pressure increase of pancreatic enzymes (such as lipase) shown in blood tests hemorrhoids upset stomach or indigestion burping gas (flatulence) bloating of the stomach inflamed stomach (gastritis) the signs include stomach-ache, feeling sick (nausea) or being sick (vomiting) reflux or heartburn also called gastro-esophageal reflux disease hair loss injection site reactions low blood sugar (hypoglycaemia) in patients with diabetes low blood pressure increase of pancreatic enzymes (such as lipase) shown in blood tests hemorrhoids Uncommon: may affect up to 1 in 100 people fast heartbeat increase of pancreatic enzymes (such as amylase) shown in blood tests feeling faint or fainting/passing out low blood sugar (hypoglycaemia) in patients without diabetes Children and Adolescents Not recommended in children and adolescents under 18 years of age as the safety and efficacy in this age group have not yet been studied
Excess iodine increases the synthesis and release of thyroid hormone in iodine-deficient patients and in older patients with preexisting multinodular goiters
Quelle: Freissmuth et al., Pharmakologie und Toxikologie, 2020, Springer Mutschler et al., Mutschler Arzneimittelwirkungen, 2019, Wissenschaftliche Verlagsgesellschaft Stuttgart Peter E
Five add-on RCTs have been done ( n = 537)
