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By simultaneously promoting bone formation and inhibiting bone breakdown, CGRP creates an environment strongly biased toward net bone building

That mechanism was validated at meaningful scale: the pivotal trial program supporting FDA approval enrolled 816 HIV-infected adults with clinically defined lipodystrophy, one of the larger controlled datasets behind any peptide discussed in this category

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Week 1-4: 1mg weekly Week 5-8: 2mg weekly Week 9-12: 4mg weekly Week 13-16: 6mg weekly Week 17-20: 8mg weekly Week 21+: 12mg weekly (if tolerated) The Phase 3 TRIUMPH-4 trial used a slightly modified approach

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CRP, C-reactive protein