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The mechanism is well-characterized

It reduces inflammation systemically, promotes new blood vessel growth, and supports the repair of damaged tissue throughout the body

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Notably, a propargyl group at P1 or alternatively an extended P1 side chain resulted both in very potent and fairly selective IRAP inhibitors, 45 (DG046) with IC50 values of 2 nM and 46 with a IC50 value of 4 nM (Figure 11)

Further Reading [1] N

Its preserved formulation helps inhibit microbial growth, making it suitable for extended use in structured research protocols