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The question of when to take retatrutide in terms of the day of the week and time of day follows the same general principles as other once-weekly injectables, based on trial protocols: Choose a consistent day each week (for example, every Monday) to maintain regularity

A 30-week randomized non-inferiority study comparing 2 mg once-weekly EX-LAR with 10 g twice-daily EX in 295 patients with T2DM

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus

I mostly stopped drinking caffeine in the mornings, and didn't get caffeine withdrawal (I have tried to quit previously and I would lead to headaches in the afternoon for the first few days)

Effective within 6-12 hours

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