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Efficacy and safety of once-weekly semaglutide versus once-daily Sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (sustain 2): a 56-week, double-blind, phase 3a, randomised trial

ArticlePubMed 26

For diabetics, the glycemic benefits may factor into compound selection

More and more, that advice describes a new way of using GLP-1s: Microdosing, or taking smaller amounts of the GLP-1 to get the benefits without as many of the potential side effects (which include things no one wants, like nausea and constipation)

For compounded tirzepatide, the initial package is listed at $349/month (originally $259 per brand)

PMID 8405712