Y-BL: Data curation, Methodology, Writing original draft
Large clinical trials running for several years show that GLP-1s not only improve sugar and weight but also reduce heart and kidney risks in many people with type 2 diabetes, with an acceptable safety profile when monitored
There have been extensive animal-based studies conducted on the functioning of IGF-1 in the body
Both trials also showed dose-dependent and marked improvements in waist circumference, lipids and blood pressure (Table 1)
It is well established that oxidative stress and reactive oxygen species (ROS) generation (probably from genetic and environmental risks) lead on one hand to GPx activation and on the other to the activation of the transcription factor NRF2, which in turn upregulate the antioxidant defense system, including GPx
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