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PBMs are responsible for: Managing health benefits for employers Negotiating discounts and rebates with drug companies Deciding which drugs get covered (generic, brand, and at what tier) Determining which pharmacies are in network Requiring prior authorization for certain expensive medications Handling the claims transaction when you pick up your prescription at the pharmacy In the 2000s, many insurance companies wanted to make horizontal acquisitions by buying their competitors to consolidate the market

The dense, heavily branched nature of mucins helps block diffusion by creating a mesh with very fine pores (Cone, 2009

163(3):764774.e1

Most available data are derived from animal models and in vitro experiments

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