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Immediately after LPS injection, there was an 83% decrease to a minimum at 3 h pi , followed by a significant increase to a peak at 24 h pi and a return to baseline level until the end of the trial

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Gagnon Eloi, Mitchell PatriciaL, Arsenault BenoitJ

This is known as receptor desensitization

GLP-1 medications have completely changed what is possible in weight management