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A 70-kg healthy adult synthesizes 1.7 g creatine per day from 2.3 g arginine, 1.0 g glycine, and 2.0 g methionine (Wu and Morris 1998), which represent 46%, 36% and 87%, respectively, of their daily dietary intakes

The optimal strategy depends on individual circumstances, comorbidities, and treatment goals

Aronoff SL, Berkowitz K, Shreiner B, Want L

They highlighted the potential of their dual mechanism effect to address limitations in current pharmacotherapies

Dudek KA, Dion-Albert L, Lebel M, LeClair K, Labrecque S, Tuck E, et al

Oral supplementation works because approximately 1% of an oral dose is absorbed through passive diffusion, bypassing the need for intrinsic factor