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The majority of renal transporters are members of the solute carrier (SLC) family of transporters and the ATP binding cassette (ABC) family of transporters

Mechanistically, exenatide stimulated the release of -endorphin from spinal cord tissue and cultured primary microglia

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As sitagliptin faces patent expiry in the coming years, ensuring a robust generic market will drive costs down

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Other relatively common side effects include: flushing or a feeling of warmth (around 20% incidence), injection site reactions such as redness or discomfort (~13%), and headache (11%)