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10.1016/j.chemphyslip.2009.03.008 33 EsterbauerH.EcklP.OrtnerA

Because no long-term human safety data exists, the conservative clinical approach treats cycling as a prudent default rather than a proven necessity

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Clinical trials showed reductions in hemoglobin A1c (HbA1c) levels of approximately 0.8% to 1.0% when added to existing oral diabetes medications, with effects varying based on baseline A1c levels