( 10.1095/biolreprod.112.102020) [DOI] [PubMed] [Google Scholar] Aliabadi E, Soleimani Mehranjani M, Borzoei Z, Talaei-Khozani T, Mirkhani H, Tabesh H.2012
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injection site reactions (redness, swelling, localised pruritus) are common, affecting 110% of patients, whilst generalised itching and urticaria are uncommon, affecting 0.11%, and may indicate a hypersensitivity reaction
Reductions in body weight were significantly greater with the LY3298176 1.5 mg, 4.5 mg and 10 mg doses versus placebo in MAD HS (LSM difference [95% CI]: -1.75 kg [-3.38, -0.12], -5.09 kg [-6.72, -3.46] and -4.61 kg [-6.21, -3.01], respectively) and doses of 10 mg and 15 mg had a relevant effect in T2DM patients (LSM difference [95% CI]: -2.62 kg [-3.79, -1.45] and -2.07 kg [-3.25, -0.88], respectively
Some studies report stable or slightly improved bone density with GLP-1 therapy, while others suggest potential decreases, particularly in the context of significant weight loss
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