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Deiodination is the primary metabolic pathway for T4 and T3, occurring mainly in the liver and kidneys

Further studies revealed that GLC increases melanin production in melanocytes by three pathways, 1) activating activator protein-1 (AP-1) and CRE promoter to activate p42/44 MAPK signaling, 2) activating cAMP signaling, and 3) decreasing GSK3 phosphorylation while inducing CREB phosphorylation (Lee et al., 2005)

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(2014) 15:I7

The weight loss acceleration typically comes in the middle and higher dose ranges