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Activation of goblet-cell stress sensor IRE1 is controlled by the mucin chaperone AGR2

By reducing the production of these, glutamate levels lower, the consequences of oxidative stress are reduced, and pro inflammatory cytokines are reduced, reducing the effects of inflammation and oxidative stress in progressing the disease and disruption of the BBB

[DOI] [PubMed] [Google Scholar] 4.Firth SM, Baxter RC

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Understanding these realities prevents disappointment and promotes healthier decision-making