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Given its complex nature, effective management often requires a multifactorial approach, incorporating glycemic control, blood pressure management, renin-angiotensin-aldosterone system (RAAS) blockade, and SGLT2 inhibitors to mitigate multiple pathophysiological disturbances simultaneously [103]

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Researchers have suggested that this distinction is significant: exogenous growth hormone can overwhelm normal feedback loops, whereas tesamorelin more closely restores a youthful hormonal secretion rhythm, which may help explain why its effects are relatively selective for visceral fat rather than producing large shifts in total body weight