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Average weight loss in the first month is 3-5 pounds, driven mainly by reduced calorie intake rather than metabolic change

SURPASS-4 participants were also older and 63% were male

What youll learn: Januvia (sitagliptin) is FDA-approved for managing type 2 diabetes, not for weight loss, and is generally considered weight-neutral

Practical Tips for Balanced Nutrition During a Calorie Deficit Maintaining nutritional adequacy whilst in a calorie deficit requires thoughtful planning

Cell viability Resazurin reduction assay Resazurin (Sigma) was added to the cell culture medium (5 g/ml) for a period of at least 30 min