Die kommerzielle Entwicklung als Medikament wurde spter eingestellt, aber die wissenschaftliche Datenbasis aus diesen Studien ist sehr gut
Hepatocyte-specific SIRT1 knockout mice exhibit impaired glucose tolerance, decreased insulin sensitivity, and elevated HOMA-IR values, supporting a protective role of SIRT1 in hepatic glucose homeostasis
While conventional treatments are effective for many, some patients may still experience residual symptoms
In studies using knockout mice for the modifier subunit of glutamate cysteine ligase (GCLM), it was shown that GSH levels decreased by 20%, while theses mice were resistant to insulin resistance, had hyperglycemia and an increased metabolic rate compared to the wild-type mice
Investigators have used bulk quantities of GSH purchased from various chemical companies
Once gene reads and counts were complete, differential expression analysis was performed using the DESeq2 R script extension within BlueBee software
