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For BSO treatment, cells were GSH starved for 48 h before washing and addition of EV-F3 and further 0.4 mM BSO (Sigma)
Next steps: continue advancing TIX100 in #T1D while further exploring its potential role in #weightmaintenance
Some long-term preclinical testing, such as animal tests of reproductive adverse effects and carcinogenicity, may continue after the IND is submitted
Its also a powerful antioxidant, helping reduce oxidative stress that can damage DNA and impair fertilisation potential
A polymorphism in the Arsenic (+3 oxidation state) MethylTransferase ( AS3MT ) gene is a strong determinant of arsenic methylation capacity and closely related to health conditions that are correlated to raised homocysteine, covered in reviews by Abuawad et al (2021) and Thomas (2021)
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