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At the final stage of the study (week 16), a reduction in LDL-4 particle fractions, a reduction in triglycerides, and a significant improvement in cellular sensitivity to insulin was observed (141)

Third, documented outcomes

Spironolactone slows down the production of androgens, hormones that help control the hair growth cycle

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doi: 10.3389/fpubh.2026.1750738 Received 20 November 2025 Revised 01 February 2026 Accepted 12 February 2026 Published 24 February 2026 Volume 14 - 2026 Edited by Ploutarchos Tzoulis, University College London, United Kingdom Reviewed by Theocharis Koufakis, Aristotle University of Thessaloniki, Greece Junxian Song, Peking University People's Hospital, China Updates Copyright 2026 Song, He, Cui, Sun, Liu, Yu, Li and Jin