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In the UK in 2016, Pfizer was fined 84.2 million after increasing the price of the widely used epilepsy drug, phenytoin, by 2,600 per cent, increasing the cost of treating 48,000 patients there from 2 million to 50 million

[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Marso SP, Bain SC, Consoli A, et al

or the paracellular route, which requires passage through tight junctions between adjacent epithelial cells

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Others require more time at smaller doses to allow the stomach to acclimate

In the meantime, pharmacies should prepare to operate under the new rules to ensure a smooth transition once the updated REMS requirements officially begin