If you're in UK, I recommend reading all these documents below UK B12 documents BSH Cobalamin and Folate Guidelines b-s-h.org.uk/guidelines/gui
Wawrusiewicz-Kurylonek N, Koper-Lenkiewicz OM, Gocik J, Myliwiec J, Pawowski P, Krtowski AJ
Miscarriage rate According to the systematic reviews by Cochrane (100), AOX therapy of infertile men was not correlated with miscarriage rates mainly due to small number of studies addressing this parameter
Similar results in gastric cancer were described by OLeary et al., whereby high-dose VitC (4 g/kg IP daily) was injected in combination with carboplatin (15 mg/kg weekly), paclitaxel (10 mg/kg) and 2Gy IR/8fx [89]
Controlled human trials exist, but they're limited in size, focused mostly on topical cosmetic use, and usually last only a few weeks or months. That means a lot of the exciting claims, especially around gene expression, systemic repair, and anti-aging effects, haven't been confirmed in large-scale human studies
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