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Important, but still enigmatic

The 2-4 hour plasma half-life might initially suggest benefit from divided doses, but the relevant biological effects persist far beyond plasma clearance

Conclusions Modulation of angiogenesis represents a promising therapeutic approach in neurodegenerative disorders

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An average weight loss of -8.1 kg and -10.2 kg was attained at the end of 56 weeks with phentermine 75 mg plus topiramate 460 mg, and phentermine 150 mg plus topiramate 920 mg, respectively