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Erastin irreversibly inhibits system Xc , leading to sustained GSH depletion and amplification of cisplatin-induced oxidative damage, which ultimately triggers ferroptosis and overcomes cisplatin resistance ( To date, no completed or published clinical trials of ferroptosis-targeted therapy have been reported in OSCC

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Ethics declarations Funding This study was funded by Novo Nordisk A/S

* and ** CTL group vs CPZ group

Patients with knee pain saw increased function and decreased pain with a 10% weight loss