A biodistribution study revealed that the accumulation of DOX in tumors was over twice as high in the DOX/LAAM GSH-CQD group compared to any other organs, whereas free DOX was mainly distributed in the liver, and the fluorescence intensity of the tumor was only half that of the liver at this time point (Fig
Steinert RE, Beglinger C, Langhans W
Antioxidants & Redox Signaling, 2013
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This shortage is most prevalent in the starting doses and is leading to extensive issues with patient access and delays in clinical trial start-up times as most of the obesity trials incorporate initiating GLP-1 agonist as part of the protocols
Overall, the market appears to be shifting toward specialized, next-generation therapies