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As a result, insulin initiation in obese patients, sulfonylureas, and complex oral combinations lose strategic relevance

Specifically, under the TGF-/ALK5 signaling pathway, the expression of Kir4.1, an inwardly rectifying potassium channel, was downregulated in the astrocyte membrane, and the polarized distribution of aquaporin 4 (AQP4) was impaired

Shufelt, Chrisandra L