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Thus, compared to other amino acid incorporation events, Sec incorporation may be less efficient, in part, due to limitations in the availability of cofactors involved in normal Sec-translation and the relative efficiency of normal translation termination events that occur at UGA stop codons

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Centrifuge anticoagulant-treated blood at 1,000 g for 10 min at 4C

Similar content being viewed by others Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons in the brain and spinal cord leading to paralysis and eventually death, usually within 3 to 5 years of diagnosis

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GSTM1/GSTT1 backstop both simultaneously when each is impaired and the absence of all three defines the most compromised Phase 2 architecture in the panel