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We have in the past shown that PDE4 inhibition can restore normal levels of GLP-1R-dependent cAMP generation in islets with increased receptor desensitisation due to loss of -arrestin 2 expression (22)

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Consistent with our previous work (22), Dpp4 hep/ mice had significantly reduced Dpp4 mRNA expression in whole liver extracts (Supplemental Figure 2A)