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Inquire whether your doctor recommends starting both simultaneously or introducing one drug first to assess tolerance

Orforglipron also showed clinically meaningful improvements from baseline across key cardiovascular risk factors

Adding a GLP-1 drug could potentially heighten that risk in certain scenarios: the medication will make your pancreas secrete insulin when you do ingest carbs, and simultaneously it suppresses glucagon (the hormone that tells your liver to release glucose)

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Drug Discovery Today, 22 (5), 796804