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As the identified di-, hexa- and decadepsipeptides are not in line with the proposed biosynthetic assembly of three ready-made tetradepsipeptides 8,9 , these findings prompted us to ask whether the candidate depsipeptide esters are released from chemically unstable NRPS-bound PCP- S -ester or TE- O -ester intermediates of cereulide biosynthesis upon transesterification with ethanol, or are formed as artifacts by esterification of free depsipeptides or as cereulide degradation products released upon ethanolysis
The DOHH gene is located on chromosome 19p13.3 and is composed of 6 exons that generate two alternatively spliced mRNAs that both encode the same 302 amino acid protein.
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T-cell function can be recuperated following administration of GSH precursors like N-acetyl cysteine and cysteine (Drge and Breitkreutz, 2000
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