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doi: 10.1016/j.ijpharm.2017.05.049 201 PeranLCamuescoDComaladaMNietoAConchaADiaz-RoperoMPet al

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The obtained active site model was further substantiated as amino acid residues Arg 166 , Arg 284 and Ser 447 were located at an appropriate distance for hydrogen bonding interaction with the carboxylate group of the substrate

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In mice, GDF-15 increases satiety and reduces food intake through actions in the central nervous system [99]

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