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Diabetologia 66(10):17801795

Several authors have described a negative correlation between CSF MHPG levels and cognitive functioning (Mann et al., 1983) and bradyphrenia (Mayeux et al., 1987) in PD patients, and others have described a relationship between CSF NE levels with severity of PD assessed by Hoehn & Yahr staging, akinesia scores, and freezing of the gait (Tohgi et al., 1993a)

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