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4.3 Cardiovascular Risk Reduction in High-Risk Patients 4.4 Glycemic Control in Combination Therapy (with Insulin or Oral Agents) Sembolic can be combined with: Metformin Sulfonylureas Basal insulin Combination therapy enhances glycemic stability while minimizing insulin dose requirements

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The isolated N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor binds exendin peptides with much higher affinity than GLP-1