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The nausea associated with semaglutide is thought to result from both peripheral effects on gastric emptying and central effects on nausea centers in the brain

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This, however, does not apply to other GLP-1RAs approved for the treatment of T2DM, including the same liraglutide (Victoza) and semaglutide (Ozempic or Rybelsus) at lower dosages, prompting several stakeholders to request an updated guidance 232 and more caution in media enthusiasm 233

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