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If a pharmacy claims they don't accept it, ask them to run it as a secondary payer using the BIN (019158) / PCN (CNRX) / Group numbers

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This is particularly consequential in post-mitotic organs such as the heart and brain, which possess limited regenerative capacity and are exceptionally vulnerable to proteotoxic stress

These in vitro studies make metformin desirable for potential repositioning as anti-cancer compounds in the treatment of TC, thus several studies are still ongoing to deeply characterize its effect

Metformin is often continued for minor procedures but may be temporarily stopped for major surgery, procedures involving contrast media, or if there's risk of acute kidney injury