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Asymptomatic smokers and stable COPD patients showed increased GSH levels in bronchoalveolar lavage, while patients with severe/very severe exacerbation periods had significantly decreased levels (101)

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This decline in function is associated with the impairment of the first enzyme (glutamate cysteine ligase or GCL)

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Factor 3: Needle gauge Smaller gauge (higher number, thinner needle) correlates with less pain on insertion but not with less post-injection soreness