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Oxidative stress as a second line of attack occurs after the onset of initial pathology, documented, for example, by the formation of superoxide radicals and hydrogen peroxide by NADPH oxidases, for example, in the response to injury-mediated inflammation

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368,369 On the contrary, the compliance of its long-term therapy is poor, 370,371 which causes a drop in gut microbial diversity and richness, notably of butyrate-producing strains, and has detrimental effects on gut health

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Statistical analyses Statistical analyses were performed using STATA version 18 (College Station, TX) via the secured VINCI workspace